Similar to the overlap observed with p300, GO analysis of biological processes by Enrichr for genes commonly affected by Cited2 and CBP identified Lefty1 , Lefty2 , Ifitm3 , Irf1 , and Gbp2 , but the enrichment did not reach statistical significance ( Supplementary Table S6A ).
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Acute Depletion of Cited2 in Embryonic Stem Cells Disrupts Gene Networks Controlling Self-Renewal, Homeostasis, and Early Cell Fate Commitment.
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The downregulation of Rad51c and Mdc1 expression in Cited2 -depleted cells was confirmed by qRT-PCR, while in the same conditions Radb9 expression was also decreased but failed to reach statistical significance ( Section 3.5 ).