P2X7R Signaling and Differential Regulation of Neuroinflammatory and Behavior Responses in Male and Female Mice During Chronic Ethanol Exposure.

Serum P2X7R levels showed a trend toward elevation in both male and female mice following CIE exposure, reflecting the ethanol-induced upregulation of P2X7R observed in microglia in prior studies [ 79 , 80 ].

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There was a trend in the reduction of ATP levels in CIE-exposed male and female mice after BBG treatment, which did not reach statistical significance ( Figure 6 A,B). 2.8.

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