Cervicovaginal Microbiome Signatures Across Cervical Disease States: A Prospective Cross-Sectional Analysis.

Diagnostics (Basel) · 2026 · PMC12985308 · PMID 41828029

Europe PMC DOI

hedged sentences

0.0120

closest p · 0.2× alpha

0.0460

boldest claim

The sentences

nominally significantp = 0.0120actually significant

Differences between HSIL and cervical cancer were nominally significant ( p = 0.0120, q = 0.0717), whereas comparisons among non-cancer categories (Normal vs.

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modestly significantp = 0.046actually significant

Additionally, current menstrual cycle phase was modestly significant (pseudo-F = 1.670, p = 0.046), implying that hormonal fluctuations may contribute to microbiome variation. 3.6.

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did not reach statistical significanceno p-value reported

The global test indicated a trend for Lactobacillus depletion across disease stages ( p = 0.0038, FDR q = 0.369), although this did not reach statistical significance after correction for multiple testing.

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