Adipocyte-driven STAT3-ANGPT2-PTGIS axis promotes cutaneous metastasis in breast cancer and represents a targetable pathway.

NPJ Precis Oncol · 2026 · PMC12987984 · PMID 41651922

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did not reach statistical significanceno p-value reported

In contrast, while high VEGFC expression was associated with a trend toward poorer OS, PFS, and DFS, these differences did not reach statistical significance.

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showed a trendno p-value reported

In terms of OS, patients with cutaneous metastasis only showed a trend toward better survival than those with multiple-organ metastasis; however, the difference was not statistically significant ( P = 0.1139).

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