Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression.

Cell Death Discov · 2026 · PMC12988869 · PMID 41741421

Europe PMC DOI

hedged sentences

0.0617

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep = 0.0617so close (0.05 < p ≤ 0.1)

7C ) in Dmp1-Cre; Lcn2 fl/fl mice, although these differences did not reach statistical significance ( p = 0.0617 and p = 0.4076, respectively).

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a strong trendp < 0.08so close (0.05 < p ≤ 0.1)

Consistent with this, Seahorse extracellular flux analysis revealed that LCN2 reduced basal respiration (showing a strong trend toward reduction; p < 0.08, Fig. 4G ) and significantly decreased ATP production (Fig. 4H ), whereas Slc22a17 knockdown blunted the effects (Fig. 4G, H ).

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