Bioresponsive PDA-GelMA hydrogel microspheres coordinate redox-immune homeostasis via controlled rhMUC13 delivery for radiation-induced intestinal injury.

Mater Today Bio · 2026 · PMC12993424 · PMID 41852881

Europe PMC DOI

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a positive trendno p-value reported

did not reach statistical significanceno p-value reported

Although this group also exhibited a positive trend towards promoting cell proliferation and migration in the colony formation and Transwell assays, respectively, these effects did not reach statistical significance.

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a clear trendno p-value reported

Consistently, in the colony formation assay, the PDA-GelMA@rhMUC13 group also showed a clear trend toward enhanced cellular proliferation ( Fig.

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an overall trendno p-value reported

In addition, 16S rRNA sequencing suggests that PDA-GelMA@rhMUC13 partially mitigates irradiation-induced gut microbiota dysbiosis, with an overall trend toward reduced inflammation-associated taxa and increased commensal/SCFA-associated bacteria, which may further support durable mucosal homeostasis.

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