Constitutional BRCA1 Methylation is associated with high level of tumoral BRCA1 methylation and homologous recombination deficiency in triple-negative breast cancer.

NPJ Breast Cancer · 2026 · PMC12996330 · PMID 41654537

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

Prognostically, constitutional BRCA1 methylation tended to associate with improved survival, while somatic-only methylation showed a trend toward poorer outcomes (p = 0.06).

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did not reach statistical significanceno p-value reported

Although the difference did not reach statistical significance, we observed a trend toward better survival among constitutionally methylated cases, suggesting a possible favorable prognostic impact that deserves further exploration in larger cohorts.

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an unexpected trendno p-value reported

This could be explained by the subset of sBRCA1 patients (only somatically methylated cases) among tBRCA1 patients, for which we observed an unexpected trend toward worse survival when compared to cBRCA1 patients.

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