Integrated analysis identifies a CXCR6/CD45/PD-1-based risk model for melanoma prognosis and intratumoral CD8+/CD69 + T-cell infiltration correlation.

Although the enrichment of CD8 + LAG-3 + T cells in the high-CXCR6 expression group did not reach statistical significance, a trend toward increased presence was observed (Fig. 4 L).

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Compared with the low-CXCR6 expression group, the high-CXCR6 expression group showed a trend toward higher proximity frequencies between CXCR6 + cells and both CD8 + T cells and CD69 + immune cells; however, these differences did not reach statistical significance (Fig. 5 E, F).

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