LDRT combined with anti-PD-1 promotes tumor regression in head and neck squamous cell carcinoma through tumor metaprogram evolution and immune cell reprogramming.

In TCGA-HNSC, CIBERSORTx-based deconvolution suggested that higher C6-like signature scores were significantly associated with worse survival, whereas higher C9-like scores showed a trend toward better survival but did not reach statistical significance (Fig. 2 h).

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