Evaluating the Effects of Glucagon-Like Peptide 1 Receptor Agonists as a Secondary Prevention in Peripheral Arterial Disease: A Meta-Analysis.

Diabetes Ther · 2026 · PMC13000097 · PMID 41697522

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showed a trendno p-value reported

In four trials, GLP-1 RAs were effective in reducing rates of peripheral revascularization, gangrene, and DFU compared with placebo [ 3 , 6 , 13 ]; however, the REWIND trial showed a trend toward increased rates [ 1 ].

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did not reach statistical significanceno p-value reported

We found that MALE tended to occur less frequently in GLP-1 RA-treated compared with placebo-treated individuals; however, the point estimate did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.