Incidence and risk factors of calcium channel blocker-related edema in hypertensive patients: A Multicenter retrospective cohort study.

PLoS One · 2026 · PMC13001965 · PMID 41855214

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approached significanceno p-value reported

In multivariate analysis, only daily standing duration remained significant (AOR: 1.92; 95% CI: 1.03–3.58), while high-dose CCB approached significance (AOR: 1.58; 95% CI: 0.97–2.57).

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did not reach statistical significanceno p-value reported

In our study, coadministration of an ACEi and/or a thiazide diuretic was associated with a trend toward a lower risk of CCB-induced edema (odds ratio 0.60; 95% CI, 0.36–1.02); however, this association did not reach statistical significance, likely reflecting the limited number of participants receiving these agents.

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