Pretreatment emotional distress and peripheral biomarkers predict immune checkpoint inhibitor response in people with advanced inoperable gastroesophageal cancer.

Commun Med (Lond) · 2026 · PMC13002868 · PMID 41588106

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

marginally significantP = 0.061so close (0.05 < p ≤ 0.1)

Elevated post-treatment PLR was associated with only a marginally significant increase in the risk of events ( P = 0.061).

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did not reach statistical significanceno p-value reported

Similarly, in the interaction analysis, the association between ED and certain PIMs did not reach statistical significance.

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approached significanceno p-value reported

Subsequently, the group survival analysis using the cutoff values of these significant biomarkers revealed that only the log-rank tests for pre-treatment MLR, post-treatment PLR, post-treatment MLR, and δ-treatment eosinophil fraction achieved statistical significance or approached significance (Fig. 5 ).

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