Cell adhesion molecule 1 is upregulated in connective tissue mast cells and potentially contributes in IgE-mediated degranulation.

Although tryptase levels in cm3E1-treated mice were lower than those in the cmIgG group, the difference did not reach statistical significance ( p = 0.0714) (Fig. 5 B; Table 1 ).

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At 1 h after DNFB application, mice treated with cm3E1 showed a trend toward reduced Evans blue dye extravasation compared with control IgG-treated mice, although this difference did not reach statistical significance (Supplementary Figure S6).

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