Efficacy and safety of PreserFlo MicroShunt versus trabeculectomy in glaucoma patients: a systematic review, meta-analysis, and meta-regression of clinical outcomes and key covariates.

BMC Ophthalmol · 2026 · PMC13003727 · PMID 41857731

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0620

boldest claim

The sentences

near-significantp = 0.056so close (0.05 < p ≤ 0.1)

Lens status and follow-up duration showed near-significant trends in the trabeculectomy arm (pseudophakia: p = 0.056; follow-up: p = 0.061), while prior glaucoma surgery and baseline medication burden were not significant effect modifiers (all p > 0.05).

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did not reach statistical significancep = 0.062so close (0.05 < p ≤ 0.1)

In contrast, age in the trabeculectomy arm and baseline IOP did not reach statistical significance, although baseline IOP in trabeculectomy demonstrated a borderline association (coefficient − 0.448; p = 0.062).

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