Global epidemiology of neonatal herpes: systematic review, meta-analyses, and meta-regressions.

In some analyses, the trend did not reach statistical significance, reflecting reduced statistical power due to the smaller number of studies included, as these were subgroup analyses restricted to subsets of studies rather than the full data set.

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Nevertheless, estimates with unclear case ascertainment methods ( Table 2 ) and those classified as high ROB for the diagnostic reliability domain (Table S8 in the Online Supplementary Document ) showed a trend toward higher reported incidence rates compared to studies using standardised methodologies or classified as low ROB, respectively, with borderline statistical significance.

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