Developmental trajectories of glutamate and the variable clinical course of ADHD in youth.

Additionally, there was a nominally significant group difference in the relationship between glutamate concentration and both connectivity within the DMN (Std. beta = 0.5, 95% CI [0.1, 0.91], t (29) = 2.53, p = 0.017) and connectivity between the DMN and central executive network (Std. beta = 0.41, 95% CI [0.04, 0.78], t (29) = 2.28, p = 0.03).

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Furthermore, although differences did not reach statistical significance, numerically more of the persistent group were medicated during the study (70% vs. 55% ever medicated) including at final follow-up (48% vs. 30%).

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