Role of Growth Hormone and Insulin-Like Growth Factor-1 in Modulating Disease Severity in Children with COVID-19 and Multisystem Inflammatory Syndrome.

Infect Drug Resist · 2026 · PMC13005183 · PMID 41868020

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.2700

boldest claim

The sentences

did not reach statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

Children with pneumonia infected with SARS-CoV-2 had lower growth hormone levels (0.99 (0.11; 2.25) ng/mL) compared to patients without lung involvement (1.35 (0.66; 4.22) ng/mL), although this difference did not reach statistical significance ( p = 0.053).

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showed a trendp = 0.270not close (p > 0.1)

An IGF-1 level <52.5 ng/mL showed a trend toward severe COVID-19 (AUC = 0.591, 95% CI [0.44−0.74], p = 0.270), whereas <44.1 ng/mL predicted MIS-C (AUC = 0.838, 95% CI [0.72−0.95], p < 0.001).

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