Prognostic Impact of Cumulative Fluid Balance in Critically Ill Patients: A Retrospective Cohort Study.

Cureus · 2026 · PMC13007817 · PMID 41878185

Europe PMC DOI

hedged sentences

0.0870

closest p · 1.7× alpha

0.0870

boldest claim

The sentences

did not reach statistical significancep = 0.087so close (0.05 < p ≤ 0.1)

An increase in serum creatinine greater than 50% from baseline occurred more frequently in patients with CFB < −3% (28.6%, n=8) compared with those with CFB −3% to 7% (17.1%, n=6) and CFB >7% (6.7%, n=2), although this difference did not reach statistical significance (p = 0.087, χ2(2) = 4.88, Cramér’s V = 0.23).

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showed a trendno p-value reported

A markedly positive CFB (>7%) was associated with higher ICU mortality and greater respiratory support requirements, whereas a markedly negative CFB (<−3%) showed a trend towards less favourable renal outcomes.

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