Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors.

Soc Psychiatry Psychiatr Epidemiol · 2026 · PMC13008129 · PMID 40885866

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approached significanceno p-value reported

Although no single early-life psychosocial factor significantly moderated the genetic risk for depressive symptoms, the interaction between cumulative adversity and genetic predisposition approached significance, aligning with previous research.

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showed a trendno p-value reported

The multiplicative interaction between cumulative early psychosocial score and PGS of MDD showed a trend towards statistical significance (p-interaction = 0.07) (Table C).

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