Clinical and immunological significance of tertiary lymphoid structure maturation heterogeneity in brain metastases of lung adenocarcinoma.

J Transl Med · 2026 · PMC13011711 · PMID 41691286

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did not reach statistical significancep = 0.092so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

In contrast, immature TLSs showed a trend toward favorable outcomes compared to TLS-negative cases, but the associations did not reach statistical significance (OS: HR = 0.78, 95% CI: 0.59–1.04, p = 0.092; PFS: HR = 0.84, 95% CI: 0.64–1.10, p = 0.207), suggesting that only fully matured TLSs convey significant survival benefit.

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