Biomimetic Architectural Cover Accelerates Osseointegration of Titanium Implants.

Although these volumetric differences did not reach statistical significance (Mann-Whitney U test; P >0.05) likely due to the limited sample size (N=3) and metallic artifacts, a clear positive trend of increased bone formation was observed, particularly within the inner ROI (thread valleys) where the scaffold bridged the gap between the implant and host bone ( Fig. 4C ). 4.

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In the rat model, micro-computed tomography analysis indicated a clear trend of increased bone formation in the Cover-type group, though statistical significance was limited by sample size.

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While micro-CT analysis indicated a positive trend in BV/TV for the Covertype group, it did not reach statistical significance.

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