FOXJ1 mediates taxane resistance through regulation of microtubule dynamics.

Conversely, another primary PC cohort showed a trend toward increased survival in the tumors with above the median FOXJ1 expression (Fig.

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In contrast, while docetaxel significantly increased DTE (higher MFI) in the control tumors, the increase in the FOXJ1 overexpressing cells was less marked and did not reach statistical significance.

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Similar to the overall cohort, this subset of men showed highly significant improvement in progression-free survival (PFS) and overall survival (OS) from the addition of docetaxel, indicating that this subset of patients is representative of the entire patient cohort (Fig.

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