Although several PUFA-enriched PCs, showed a trend toward recovery in the ReAdm group, their levels remained persistently reduced, suggesting prolonged metabolic imbalance.
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Plasma lipid remodeling during the early recovery phase after myocardial infarction.
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The sentences
Although these correlations did not reach statistical significance after correction for multiple testing, the observed trends suggest a potential relationship between myocardial injury severity and alterations in polyunsaturated and ether-linked phospholipids.
In the comparison between MI and healthy controls (left panel), the ether lipid metabolism pathway showed the strongest perturbation, characterized by the combination of highly significant enrichment (lowest p-values) and the largest pathway impact.
Pathways linked to α-linolenic acid metabolism and glycosylphosphatidylinositol (GPI)-anchor biosynthesis appeared weakly perturbed in both comparisons, showing marginal significance and minimal pathway impact.