Functional distinctions between orbitofrontal cortex and anterior cingulate cortex subregions in decision-making and autonomic regulation.

Nat Commun · 2026 · PMC13018591 · PMID 41690910

Europe PMC DOI

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closest p · 1.2× alpha

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marginally significantp = 0.06so close (0.05 < p ≤ 0.1)

During the reward delivery event, the cOFC did not exhibit a significant trend (t(4) = − 0.29, p = 0.78), but the pACC exhibited a marginally significant effect (t(4) = − 2.55, p = 0.06).

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showed a trendno p-value reported

The cOFC units showed a trend to be more active across most task events.

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a significant trendno p-value reported

These findings demonstrate a significant trend for the cOFC units recorded to be more actively involved during events related to reward processing and the initiation of trials, possibly linked to attentional and reward-evaluation processes, whereas the pACC units recorded showed greater involvement during events associated with aversive outcomes, such as the delivery of airpuffs following particular choices or cues.

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