Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model.

Although decreased plasma NfL by S1D12 did not reach statistical significance ( p = 0.1478), this is not surprising given the small number of mice and biological variance of the data.

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Although the data only showed a trend towards a reduction ( p = 0.15), the blockade of NfL increase is further confirmed by the lack of difference between 2-month-old controls and the 5-month-old S1D12 mice.

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Nevertheless, the large effect size (60% inhibition) in the young mice is encouraging and the finding is further supported by the highly significant correlations between NfL and tau pathology endpoints.

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