Preservation of miR-9-5p and miR-124-3p in ALS-resistant oculomotor neurons contrasts with their downregulation in vulnerable spinal motor neurons, irrespective of TDP-43 pathology.

Acta Neuropathol · 2026 · PMC13021698 · PMID 41888437

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showed a trendno p-value reported

In contrast, we failed to detect statistically significant reductions in miR-9-5p or miR-124-3p expression in ALS OMNs in this methodological framework; in fact, miR-9-5p showed a trend toward increased expression in ALS.

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did not reach statistical significanceno p-value reported

This is particularly relevant for miR-124-3p, which was reduced by 42.9% in ALS (control cases = 3) but did not reach statistical significance.

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