Myo-inositol elevation as an in vivo marker of reactive gliosis in pediatric Friedreich ataxia: evidence from HERMES-edited MR spectroscopy.

In contrast, there was a highly significant main effect of ROI (p < 0.001), with GSH levels significantly lower in both motor cortices compared to the cerebellum, consistent with a regionally specific gradient in glutathione concentration.

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ROI-specific Welch t-tests showed a trend toward reduced tNAA in the left motor cortex (p≈0.08; Cohen’s d ≈ 0.67), with a smaller difference in the right motor cortex (p≈0.27).

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tNAA (motor cortex and cerebellum) Although group differences in tNAA did not reach statistical significance in the primary linear mixed-effects model, inspection of the regional data suggested that tNAA values were numerically lower in FRDA, particularly in the motor cortices.

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