Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation.

In contrast, HSP60 expression displayed a decreasing trend in the Hsp70 −/− group, although this reduction did not reach statistical significance ( Figure 4 B). 4.

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The upregulation of HSP90 in the absence of HSP70 could potentially ameliorate the inflammatory processes since it has been recently shown that selective and combined inhibition of HSP90a and HSP90b showed a trend toward increased inflammatory activity [ 37 ].

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