Persistent Low-Grade Squamous Intraepithelial Lesions and the Risk of Overtreatment: Evidence from Long-Term Active Surveillance.

The association showed borderline significance by the Wald test ( p = 0.074) and was supported by the likelihood ratio and score tests ( p = 0.03 and p = 0.04, respectively) ( Table 4 ).

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In Cox regression analysis, HPV16 positivity showed a higher estimated hazard of CIN3; however, the association did not reach statistical significance and confidence intervals were wide, reflecting the limited number of outcome events.

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In the Cox regression model, HPV16 positivity showed a trend toward an increased hazard of progression to CIN3, although the estimate was imprecise and did not reach statistical significance ( p = 0.146) ( Table 2 ).

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