Pan-Cancer Targeted Sequencing Reveals Genomic Heterogeneity and Prognostic Subgroups in Urothelial Bladder Cancer.

Although FGFR3 -mutant tumors in our cohort showed a trend toward improved survival, this association did not retain independent significance in multivariable models, likely reflecting the strong correlation between FGFR3 activation and favorable clinicopathological features such as lower grade and stage and co-occurrence with protective alterations including STAG2 .

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FGFR3 mutations were associated with a trend toward improved OS but did not reach statistical significance in multivariable models.

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