Tumor Size Modifies the Survival Benefit of Chemotherapy in Localized Soft Tissue Sarcomas: A Propensity-Matched Cohort Study.

J Clin Med · 2026 · PMC13026149 · PMID 41899177

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

showed a trendp = 0.063so close (0.05 < p ≤ 0.1)

For tumors 5–10 cm, chemotherapy showed a trend toward improved survival (HR = 0.45, 95% CI: 0.19–1.05, p = 0.063).

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did not reach statistical significanceno p-value reported

Synovial sarcoma demonstrated a directionally protective association with chemotherapy in medium-sized tumors, although this finding did not reach statistical significance and attenuated after weighting analyses.

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