Clinical, Dermatoscopic, Histological and Molecular Prognostic and Predictive Factors of Metastatic Melanoma Response to Immunotherapy: A Systematic Review and Drug Class Meta-Analysis.

J Clin Med · 2026 · PMC13026811 · PMID 41899070

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

showed a trendp < 0.01actually significant

When pooled across studies, TMB-high compared with TMB-low showed a trend toward improved PFS (pooled HR 0.47, 95% CI 0.33–0.7, p < 0.01).

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did not reach statistical significanceno p-value reported

In the present meta-analysis, the pooled random-effects hazard ratio for the impact of liver metastases on overall survival was 1.88 (95% CI 0.77–4.60), indicating a trend toward worse survival in patients with liver metastases; however, this association did not reach statistical significance, as shown in Figure 31 .

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borderline significantno p-value reported

The pooled random-effects hazard ratio was 1.52 (95% CI 1.00–2.33, p = 0.05), suggesting a borderline significant association between the presence of brain metastases and worse PFS, as shown in Figure 28 .

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