The Signal in the Extreme: A Systematic Outlier Framework Identifies Discrete Immunometabolic Subtypes in Human and Cellular Models.

Med Sci (Basel) · 2026 · PMC13027428 · PMID 41892843

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did not reach statistical significanceno p-value reported

IL-17 ( p = 0.17) and RORγT ( p = 0.32), despite their descriptively extreme elevations, did not reach statistical significance in the inferential analysis.

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showed a trendno p-value reported

The receptor Tnfrsf1b showed a trend towards lower expression in outliers (median: 0.32 vs. 0.31), although with overlapping ranges. 3.11.

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