Leveraging Large and Diverse Biobanks to Evaluate Gene-Disease Associations in Hypertrophic Cardiomyopathy.

J Pers Med · 2026 · PMC13028266 · PMID 41893039

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nominally significantno p-value reported

Results: Of the 12 genes with definitive evidence for HCM (e.g., MYBPC3 , MYH7 , TNNT2 , ALPK3 ), 8 (67%) demonstrated nominally significant association with HCM on a population level, and 5 (42%) remained significant after Bonferroni correction, further supporting the validity of these genes in HCM panels.

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did not reach statistical significanceno p-value reported

There were seven genes classified by ClinGen as “definitive” that were either nominally significant but did not reach statistical significance after Bonferroni correction ( CSRP3 , MYL3 , and ACTC1 ) or never reached nominal significance ( TPM1 , FHOD3 , MYL2 , and TNNC1 ).

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