Novel Insights on Clinical Outcomes Using Integrated Shotgun Metagenomic Profiling of the Gut Microbiome, Resistome, and Host Immune-Inflammatory Response in Hospitalized Patients with Decompensated Cirrhosis.

Accordingly, readers should interpret individual associations—particularly those involving genes with borderline significance or smaller effect sizes—with appropriate caution.

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Similarly, ICU admission, ascites, and elevated nCD64 showed only trending associations with reduced Shannon diversity that did not reach statistical significance.

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The near-significant trend for ascites supports a relationship with reduced diversity, though our binary classification (present/absent) rather than severity grading may have attenuated the signal.

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