Design, Synthesis, and Structure-Activity Relationships of Substituted Phenyl Cyclobutylureas as Potential Modulators of Inflammatory Responses.

In contrast, compound 16b , bearing a meta-cyano substituent, displayed IL-6 inhibition comparable to dexamethasone, although the difference did not reach statistical significance.

also in 111,027 other papers

Notably, compounds 4b (para-methoxy), and 10b (para-cyano; the positional isomer of 16b ), showed a trend toward higher IL-6 inhibition, although the effects remained modest and did not reach statistical significance.

also in 53,322 other papers