Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy.

At P14, the mRNA and protein levels of mutant AR in the spinal cord were reduced by approximately 50% and 25%, respectively, but these reductions did not reach statistical significance (Supplementary Fig. 3 ).

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Gria1 expression was similar between the two groups at 7–9 weeks but showed a trend toward downregulation in AR-97Q mice at 10–12 weeks of age (Supplementary Fig. 8h ).

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