Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis-Associated Interstitial Lung Disease.

Patients with anti‐Scl‐70 autoantibodies had a strong trend toward having progressive disease ( P = 0.0783), whereas patients with anti‐centromere (ACA), anti‐U1 or anti‐U2, and anti‐Th or anti‐To antibodies were associated with less progressive disease ( P = 0.1796 for each; Table 1 ).

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Both genes showed a weak trend toward differences between patients with progressive SSc‐ILD and patients with stable SSc‐ILD in bulk RNA‐seq.

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Regarding markers identified in CD14+ monocytes, LOXHD1 showed a trend toward increased expression in CD16+ monocytes but its level of expression was much lower than in CD14+ monocytes.

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