Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation.

Int J Mol Med · 2026 · PMC13034899 · PMID 41891961

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showed a trendP>0.05actually significant

Notably, the Nrf2/HO-1 expression levels showed a trend toward upregulation in the SCI group compared with the Sham group (P>0.05), suggesting a possible endogenous compensatory response to injury-associated oxidative stress.

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did not reach statistical significanceP>0.05actually significant

Similarly, erastin treatment tended to increase Nrf2 and HO-1 expression compared with the Control group; however, the differences did not reach statistical significance (P>0.05) ( Fig. 2A-C ).

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