Sarcopenia, body composition, physical performance, and clinical features in Parkinson's disease: a cross-sectional comparative study.

( 46 ) reported that declines in total body and fat mass started approximately 6–7 years before diagnosis, although reductions did not reach statistical significance until around 3–5 years following diagnosis, and 96% of the weight loss was due to fat mass reduction ( 46 ).

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Although sarcopenia prevalence did not differ significantly, PD patients scored higher on the SARC-F overall and across most domains, performed worse on SPPB balance, and showed a trend toward lower handgrip strength and appendicular skeletal muscle mass index across quantiles, with a significant reduction in muscle mass at the 40 th percentile.

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