Cardioprotective effects of puerarin against myocardial ischemia-reperfusion injury: a preclinical systematic review and meta-analysis.

Front Pharmacol · 2026 · PMC13036222 · PMID 41924138

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showed a trendP = 0.01actually significant

Similarly, 10 studies showed a trend toward lower CK-MB levels compared with controls (n = 10; SMD = −4.35; 95% CI: −5.59 to −3.11; heterogeneity: I 2 = 57%; P = 0.01; Figure 4C ).

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did not reach statistical significanceP = 0.01actually significant

Two studies reported a numerical decrease in IL-1β levels with puerarin intervention, but the difference did not reach statistical significance (n = 2; SMD = −3.23; 95% CI: −6.68 to 0.23; heterogeneity: I 2 = 84%; P = 0.01; Figure 7A ).

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