Neutrophil-to-lymphocyte ratio half reduction as a surrogate of molecular response in polycythemia vera treated with ropeginterferon alfa-2b.

NLR half reduction was associated with a lower odds of thrombotic or myelofibrotic events (OR 0.17, 95% CI: 0.003–2.18), although this association did not reach statistical significance due to the small number of events (Fisher’s exact test, p = 0.119).

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While raw NLR showed a trend toward positive correlation, a statistically significant association was observed with log-transformed NLR ( Figures S1 and S2 ), supporting its relevance as a marker of molecular disease activity.

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