Local Promoter Methylation Disorder algorithm reveals bidirectional epigenetic disruption in DNMT3A-mutated AML and predicts azacitidine treatment response.

Front Oncol · 2026 · PMC13038435 · PMID 41930195

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

nominally significantp < 0.05actually significant

Benjamini-Hochberg FDR less than 0.05 was used as the significance threshold; nominally significant pathways ( p < 0.05) were also reported to provide biological context for exploratory analyses.

also in 7,732 other papers

showed a trendno p-value reported

In PC1-PC2 space, DNMT3A mutant samples showed a trend toward warmer tones (higher LPMD values of 0.40-0.42), whereas wild-type samples predominantly displayed cooler tones (lower LPMD values of 0.35-0.37).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.