Significance of LEF1, ROR2, Cyclin D1, and DNA Methylation Profiling in the Molecular Classification and Prognosis Prediction of Pediatric Medulloblastoma.

Balkan Med J · 2026 · PMC13040109 · PMID 41521603

Europe PMC DOI

hedged sentences

0.0870

closest p · 1.7× alpha

0.0870

boldest claim

The sentences

of borderline significancep = 0.087so close (0.05 < p ≤ 0.1)

At 5 years, tLEF1 remained significantly associated with better OS ( p = 0.042), whereas the association for pLEF1 was of borderline significance ( p = 0.087).

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did not reach statistical significanceno p-value reported

Although the mean pLEF1 H-score was higher in SHH-AG cases than in other molecular groups, this difference did not reach statistical significance for molecular subgroup discrimination.

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near-significantno p-value reported

18 observed a near-significant association between β-catenin and Cyclin D1.

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