Timing-dependent effects of green tea supplementation and exercise intensity on oxidative stress in diabetic rats: a 2 × 2 × 2 factorial study.

The interaction between tea extract and exercise timing did not reach statistical significance ( p = 0.071), although it showed a trend toward a small to moderate effect size (ƞ 2 = 0.06).

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Circadian effects may not be significant in nocturnal animals.

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Most notably, the three-way interaction between tea extract, exercise intensity, and exercise timing showed a highly significant effect with a large effect size (ƞ 2 = 0.26), indicating that oxidative stress reduction is most optimally achieved through an integrated combination of interventions. 3.4.

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The combination of standardized green tea extract with moderate-intensity exercise performed in the morning (light-phase) produced the greatest reduction in MDA levels and showed a trend toward normalization when compared with normal controls.

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