Curcumin reduces neuroinflammation and oxidative stress in a stroke model by epigenetically regulating ADRB2 methylation through JAK2/STAT3 and Nrf2/HO-1 pathways.

Although siRNA-mediated knockdown of ADRB2 showed an increased trend in markers of inflammation and oxidative stress, these results did not reach statistical significance, although successful ADRB2 knockdown was confirmed by Western blotting and PCR.

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Although the MCAO + Vehicle group mice showed a trend of self-recovery of blood flow over time, there were significant differences compared to the treatment group mice (Fig. 6 B-C).

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TET1 expression increased at low concentrations and showed a decreasing trend with increasing concentration.

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