Source-dependent variability in gut barrier disruption, bacterial translocation, and immune activation after ischemic stroke in Wistar rats.

Animal Model Exp Med · 2026 · PMC13042938 · PMID 41749040

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a strong trendno p-value reported

In RjHan rats, ischemic animals with BT exhibited a significant increase in contrast signal intensity in the spleen and a strong trend toward increased signal in the MLN, indicative of barrier disruption.

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did not reach statistical significanceno p-value reported

Quantification of total bacterial load across all analyzed organs showed a lower overall bacterial burden in RccHan rats compared with RjHan rats; however, this difference did not reach statistical significance (Figure 2C ).

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