Extramedullary hematopoietic niches support the initiation and progression of myeloid malignancy in the murine spleen.

Analyses performed immediately prior to death showed a trend toward reduced spleen weight (Supplementary Fig.

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CXCL12 and SCF expression was also elevated, although the increase in SCF did not reach statistical significance (Fig. 2 d).

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Proerythroblasts showed a decreasing trend, and both erythroblasts and erythrocytes were significantly reduced (Supplementary Fig.

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