Reduced cytochrome P-450 (CYP) 2D6 activity and Plasmodium vivax malaria risk in Amazonians: A retrospective, population-based cohort study.

PLoS Negl Trop Dis · 2026 · PMC13048497 · PMID 41894411

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closest p · 1.6× alpha

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boldest claim

The sentences

did not reach statistical significanceP = 0.080so close (0.05 < p ≤ 0.1)

The association between null/low CYP2D6 activity (AS ≤ 0.25) and vivax malaria incidence did not reach statistical significance among the youngest participants (IRR = 1.65, P = 0.080) and did not change significantly in the older age groups ( P = 0.090 for 17–40 years and P = 0.343 for > 40 years) ( Table 5 ).

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difference was apparentno p-value reported

No such difference was apparent among older participants.

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