Morbidity and mortality in alcohol use disorder: the role of comorbid substance use disorder, age, sex, and the A1 allele of the Taq1A (rs1800497) polymorphism in the ANKK1 gene in an 18-year follow-up.

In contrast, when testing the interaction between poly-SUD and the A1 allele of the Taq1A polymorphism (A1+) (Model 3), a trend towards significance in model fit was observed (LR χ 2 (1) = 3.36, P = .067), suggesting a possible synergistic effect of genetic and poly-SUD on mortality.

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In the present analysis, a trend towards an interaction between poly-SUD and the A1 allele of the Taq1A polymorphism was observed; however, this interaction did not reach statistical significance and confidence intervals overlapped.

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In contrast, neither poly-SUD nor the A1 allele of the Taq1A polymorphism showed an independent association with mortality, although the genetic effect showed a trend towards significance, suggesting that Taq1A genetic variation may modestly contribute to adverse outcomes in AUD.

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